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Low-cost new mirror peptide can be 上海qm体验报告 neutralized with new crown viruses

  Science and Technology Daily News (Reporter Liu Xia) According to the physicist network recently reported that Canadian researchers have developed compounds-D-peptides that can neutralize new crown viruses and variants, can neutralize viruses and prevent their infection Laboratory cultivated human cells. These compounds are called mirror peptides, with unique chemical properties, suitable for developing low-cost antiviral therapies.

The main author of this study, Toronto University Molecular Genetics and Professor of Computer Science, Philipkin, said: "A great advantage of mirror peptides can remain stable for a long time, and the production cost is relatively low.

You can imagine use them into a nasal spray for preventing infection. "Peptide and proteins 上海龙凤网工作室 are consisting of amino acids," personality "is similar. However, the peptide is smaller than protein molecules, which can be combined with almost any molecular target, which is more specific, which can reduce the risk of side effects. Aspects, peptides are similar to antibodies, but due to their small size, production costs can be cheaper to 1/100, so low cost and easy to expand production, this is attractive, especially in low-income countries. But Yes, in the human body, the peptide will be rapidly degraded by certain enzymes.

The study of the Golden Team found that mirror peptides can resist degradation. A few years ago, the Golden Team has developed a computing tool for designing a so-called D-peptide. These mirrored molecules are formed together by the synthetic D-amino acid strings, which can bind to the same target without reducing specificity, and their unusual geometry has resistance to the enzyme of decomposing the normal L-peptide in the blood. The prospect of the D-peptide attracted the attention of Pedro Valentine Postdoctoral researchers, and he realized that they can use their tools to make antiviral drugs for new coronal pneumonia.

To this end, several D-peptides were designed to simulate the prolinus region of the virus bonded to the cell surface ACE2 receptor. Varente inferred that the viruses were in contact with the receptor, and the peptide was combined with the receptor to prevent infection – this assumption was later confirmed by the human cell experiments cultivated by Korean partners.

  Gold said, more importantly, these peptides also play the same role in the new crown virus Alpha, Beta, and gamma variant strains.

Although they have not investigated Delta variants, other evidence suggest that it will also be sensitive to peptide drugs.

At present, the researchers are trying to make mirror peptide compounds against all coronaviruses, and it is desirable to design a general therapy to prevent the epidemic that may occur in the future.